17 Best Healthcare APIs for App Developers

80% of consumers have used telemedicine at least once. With the increasing demand for digital healthcare, developers need easy access to the systems and data that underpin modern care.

A healthcare API lets your app connect to health data or clinical tools, such as patient records, EHR systems, drug information, symptom checkers, or secure chat and video.

This guide compares the best healthcare APIs for app developers. It groups them by function, including patient data, telehealth and communication, symptom checking, drug data and pharmacy, clinical data management, EHR, and public health data.

TL;DR: Healthcare APIs Compared

This table compares the 17 healthcare APIs in this guide by their use case, interface and standards, and access directions. Each API gets its own section below with more detail.

Types of Healthcare APIs

Healthcare APIs fall into seven types, based on the job they do in your app.

• Patient data: Bring records from EHRs, labs, and health networks into one view (Apple Health Records, Particle Health, Redox, Metriport).
• Telehealth and communication: Support virtual visits, HIPAA-compliant chat, and video (Stream, eVisit, DrChrono).
• Symptom checkers: Help patients describe symptoms and get care guidance (Infermedica, Isabel).
• Drug data and pharmacy: Check drug interactions and allergies, or fulfill prescriptions (PEPID, FuzeRx).
• Clinical data management: Store, de-identify, and analyze clinical data (Google Cloud Healthcare API, Amazon Comprehend Medical).
• EHR: Read data from a specific EHR system (Veradigm, Meditech).
• Public health: Add statistics and vetted health content from public agencies (WHO, HHS).

How to Choose

We recommend checking eight things before you select a healthcare API, starting with compliance and access.

• Compliance and BAA. If the API handles PHI, ask whether the vendor signs a business associate agreement (BAA). No API makes your app HIPAA compliant on its own, so read each claim closely. For example, AWS says Comprehend Medical may not find all PHI and does not by itself meet HIPAA de-identification requirements.
• Standards. For records and EHR data, look for FHIR R4, US Core, and SMART on FHIR. Some vendors still offer the older DSTU2 version, so confirm which version you will get.
• Who can get access. Access rules differ. Veradigm offers free FHIR accounts, Particle Health requires a covered entity or a BAA, and Mayo Clinic, Isabel, and PEPID work through sales contact. Check this before you build.
• Data coverage. For patient records, ask which networks the API connects to, such as CommonWell and Carequality. Around 1 billion health records have now been exchanged through TEFCA, the national exchange framework.
• Sandbox and documentation. A test environment with realistic data lets you build before you sign a contract. Meditech and Particle Health both offer sandboxes.
• Authentication and security. OAuth 2.0 and SMART on FHIR are common. Ask for audit reports, such as the SOC 2 Type 2 report and HITRUST assessment that Particle Health lists.
• Pricing model. Models include usage-based pricing (Comprehend Medical), paid membership tiers (Veradigm Integrator plans), and quotes from sales.
• Reliability and support. Ask about uptime commitments, support response times, and where your data is stored.

17 APIs, Compared

The APIs below are grouped by what they do. In each entry, you'll find an overview of the API, who it suits, its key specs, and its main limitation.

Consolidated Patient Data APIs

Consolidated patient data APIs pull records from EHRs, labs, and health networks into one place, so your app can show a full patient history. The right choice depends on where the data lives. This could be on the patient's device, in national networks, or inside hospital EHRs.

1. Apple Health Records

Apple's HealthKit lets an iOS app read a person's clinical records after they download them to the Health app from supported healthcare institutions. Each record is a FHIR resource, such as a condition, procedure, or lab result, and the system refreshes the records in the background.

• Standards: FHIR
• Access: Your app must ask for the user's permission for each record type it reads.
• Limitation: You get only the records a person has loaded into the Health app, so coverage differs from user to user.

2. Particle Health

Particle Health lets you query a patient's records across national health data networks by sending basic demographics, such as name, phone number, and address. Patients do not need to log in to their own portals.

• Standards: FHIR R4, HL7 v2 event notifications, and clinical documents
• Access: You must be a HIPAA-covered entity or hold a BAA with one to query under the Treatment purpose of use. Vendors that sell to covered entities can also set up the API for their clients.
• Security: SOC 2 Type 2 report and HITRUST i1 Validated Assessment
• Sandbox: Yes, with realistic test patients
• Limitation: Access depends on your purpose of use, so confirm your app qualifies before you build.

3. Redox

Redox offers one standardized API that connects your app to more than 90 EHRs. It translates data between formats, including FHIR, HL7, X12, and JSON, and it supports two-way exchange with writeback into the EHR.

• Standards: FHIR, HL7, X12, and JSON, plus 27 custom EHR APIs
• Security: HITRUST certification and a SOC 2 Type 2 report
• Limitation: Redox routes data between systems rather than acting as a patient data store, so plan where your app keeps the data.

4. Metriport

Metriport is an open-source API that pulls patient records from national health information networks, including CommonWell, Carequality, TEFCA, and eHealth Exchange. It returns data as FHIR R4, C-CDA, and PDF, and it says it covers more than 300 million patients.

• Standards: FHIR R4, C-CDA, and PDF
• Security: Metriport states that it is SOC 2, HITRUST r2, and HIPAA compliant.
• Sandbox: Yes
• Limitation: Metriport was founded in 2022, so it has a shorter track record than older vendors.

Telehealth & Communication APIs

These APIs support virtual visits. Some are complete virtual care platforms, and some are chat and video building blocks you use inside your own app. Choose a platform if you want a ready-made visit workflow. Choose building blocks if you are building your own patient and provider app.

5. eVisit

eVisit is a virtual care platform for health systems and healthcare organizations. Patients join a visit from a link or an intake form with no app download, and clinicians can start a visit from inside an existing EHR using SMART on FHIR. eVisit acquired Bluestream Health in 2023, which added Bluestream's language services.

• Integration: SSO sign-in, patient portal integration, and SMART on FHIR launch from the EHR
• Compliance: eVisit describes its platform as HIPAA compliant
• Pricing: Custom quotes
• Limitation: eVisit is a complete platform, not a toolkit for building your own video features, so you adopt its visit workflow.

6. DrChrono by EverHealth

DrChrono is a cloud EHR and practice management platform that includes telehealth, scheduling, and billing. Its API lets developers work with data such as patients, appointments, clinical notes, documents, and billing items.

• Standards: REST API v4 and SMART on FHIR
• Access: OAuth 2.0. Production access starts by contacting DrChrono, and sandbox accounts are available.
• Limitation: The API works only with practices that use DrChrono's EHR.

7. Stream

Stream provides HIPAA-compliant chat, video, feeds, and moderation APIs and SDKs, with pre-built UI components, for adding secure communication features to a telehealth app. Features include file sharing, push notifications, and voice and video calls.

• Compliance: HIPAA-ready with a BAA, plus SOC 2 and ISO 27001
• Integration: Webhooks and SQS integration, audit logs, and SSO, SAML, and 2FA
• Reliability: 99.999% uptime SLA for Enterprise plans
• Access: Start for free. Contact sales to sign a BAA before handling PHI.
• Limitation: Stream provides the communication building blocks, not a full telehealth product, so you build scheduling, records, and clinical workflows yourself.

Symptom Checker APIs

Symptom checker APIs help patients describe what they feel and get guidance on what to do next. They are often paired with triage tools and chatbots. Keep in mind, they support care decisions and do not replace a clinician.

8. Infermedica

Infermedica's Medical Guidance Platform offers AI-driven symptom assessment, triage, and navigation to the right level of care. Its interview asks follow-up questions, then returns the most probable conditions, a triage level, and a specialist recommendation. It offers two APIs: the Platform API, with ready-made triage, intake, and follow-up interviews, and the Engine API, for custom builds.

• Integration: Platform API (stateful, with pre-defined interviews) and Engine API (stateless, for custom solutions)
• Data: The Engine API accepts de-identified information only. The Platform API stores personal data, with contact details kept for up to 90 days, and offers an anonymous mode.
• Certification: The Medical Guidance Platform, including the Platform API, has EU MDR Class IIb certification.
• Access: Request access via Infermedica's developer portal.
• Limitation: You must choose between the two APIs. The Platform API is faster to launch but stores personal data, while the Engine API avoids that and leaves more for you to build.

9. Isabel

Isabel offers a white-label API that you can embed in an app, portal, chatbot, or call center tool. It has two products: Isabel Self-Triage, where patients answer 11 standard questions to get a care recommendation, and the DDx Companion, which helps clinicians widen a differential diagnosis. Patients can type any number of symptoms in everyday language or pick them from a list.

• Integration: Headless JSON API with full white-label branding
• Coverage: Isabel says its engine searches more than 6,000 conditions, and it says the API is available in virtually any language.
• Isabel's own figures: The correct diagnosis appears in its top 10 results 96% of the time, and the engine has more than 20 validation studies or articles.
• Pricing: Contact Isabel directly for pricing information.
• Limitation: The accuracy and validation figures come from Isabel, so ask for the studies and the pricing before you commit.

Drug Data and Pharmacy APIs

These APIs help apps check medications and connect patients with pharmacies. PEPID supplies drug information for clinical systems, and FuzeRx handles prescription fulfillment.

10. PEPID

PEPID offers a drug and clinical knowledge base that you can build into EMRs, EHRs, and e-prescribing systems. It includes drug-drug interaction alerts across prescriptions, over-the-counter drugs, herbals, supplements, and foods, along with drug-allergy alerts, IV compatibility checks, and more than 3,000 dosing calculators.

• Integration: API, SDK, and InfoButton support
• Content: U.S., Canadian, and international drug names, with alerts you can tune by interaction severity, patient history, and custom drug lists
• Content review: PEPID says its drug data is continuously updated and reviewed by clinicians in partnership with the American Society of Health-System Pharmacists (ASHP).
• Access: Contact PEPID about integration.
• Limitation: Integration is arranged through PEPID, so expect a sales process.

11. FuzeRx

FuzeRx is a digital pharmacy platform from Fuze Health. Its RESTful JSON APIs cover both pharmacy and telehealth. The fulfillment API works with three objects: a patient, a prescription, and a fill request. It delivers medications to patients in all 50 states, and a patient safety API supports drug utilization reviews.

• Format: RESTful JSON API
• APIs: Pharmacy fulfillment, patient safety, and telehealth
• Accreditation: URAC accredited
• Access: Contact Fuze Health sales.
• Limitation: FuzeRx fills prescriptions through its own pharmacy, so it fits programs that dispense through Fuze Health more than apps that only need drug information.

Clinical Data Management APIs

Clinical data management APIs store, standardize, and analyze clinical data. They suit provider-facing apps where doctors and administrators need to combine records, remove PHI, or pull structure out of notes.

12. Google Cloud Healthcare API

Google Cloud Healthcare API stores and exchanges healthcare data in three formats: FHIR, HL7 v2, and DICOM imaging. Each format has a standards-based data store with read, write, and search operations. The API can also de-identify FHIR data by writing cleaned copies to a separate store and leaving the original data unchanged.

• Standards: FHIR (DSTU2, STU3, R4, and R5), HL7 v2, and DICOM
• Compliance: Covered by the Google Cloud HIPAA BAA, so you can use it with ePHI when it is configured correctly
• Data location: You choose the region for each dataset.
• De-identification: Available at the dataset level and the FHIR store level
• Access: A Google Cloud project
• Limitation: It is infrastructure, not a ready-made app feature, so you configure security and de-identification rules yourself.

13. Amazon Comprehend Medical

Amazon Comprehend Medical reads clinical text, such as physician notes or trial reports, and returns medical entities and PHI. It can link conditions, medications, and other concepts to ICD-10-CM, RxNorm, and SNOMED CT codes. It supports real-time analysis and batch jobs, and it works with English text only.

• Standards: Links to ICD-10-CM, RxNorm, and SNOMED CT
• Access: An AWS account
• Pricing: Usage-based
• Limitation: AWS says its PHI detection may not find all PHI and does not by itself meet HIPAA de-identification requirements, so you are responsible for reviewing its output.

EHR APIs

EHR APIs let your app read data from a specific EHR system, such as a patient's history, medications, or schedule. Each API works only with that vendor's customers, so pick the one that matches the health systems you serve.

14. Veradigm

The Veradigm FHIR API gives your app read-only access to selected clinical, demographic, and facility data in Veradigm EHR. It supports FHIR R4 and USCDI. To write data back, Veradigm Connect offers the Unity API, which supports both reads and writes. Unity is also the only way to read or write patient demographic, appointment, or financial data in Veradigm Practice Management.

• Standards: FHIR R4 with USCDI (read-only) and the proprietary Unity API (read and write)
• Access: Open accounts are free for the FHIR API. Unity needs a paid Integrator membership (Bronze to Platinum Plus).
• Limitation: The FHIR API is read-only, so writing data back or connecting to practice management requires the paid Unity API. Veradigm stopped supporting DSTU2 in June 2025, so build on R4.

15. Meditech

Meditech's Greenfield Workspace is a test environment where developers try its APIs against a real Meditech Expanse EHR. It offers US Core FHIR R4 APIs that give view-only access to patient-facing data after a patient authorizes an app, plus FHIR Scheduling APIs for Expanse customers.

• Standards: US Core FHIR R4 and FHIR Scheduling
• Access: Register for Greenfield Workspace.
• Limitation: Greenfield is a test environment and is not connected to customer systems, so you need a separate connection to each Meditech customer.

Public Health APIs

Public health APIs add statistics and vetted health content from public agencies to your app. They are useful for provider-facing portals, analytics tools, and patient education.

16. WHO Global Health Observatory OData API

The Global Health Observatory (GHO) gives you WHO health data through an OData interface. The data covers more than 1,000 indicators for 194 WHO member states, such as life expectancy, immunization, and disease burden. This API replaces the older Athena API, which WHO no longer maintains.

• Standards: OData
• Access: Public data through the GHO OData interface
• Limitation: WHO has said it would replace this OData interface with a new implementation that uses standard field names, so check WHO's current documentation before you build.

17. HHS Content Syndication & MyHealthfinder

HHS offers two free ways to add its health content to your app. Content Syndication lets you show content from HHS and its partners, such as the FDA, CDC, NCI, and NIH, on your site or app. You can copy JavaScript or iframe snippets, or connect the service to your content management system. The MyHealthfinder API, from HHS's Office of Disease Prevention and Health Promotion (ODPHP), provides plain-language content on preventive care, such as screenings and vaccines, in English and Spanish.

• Format: Content Syndication offers an API, JavaScript and iframe snippets, and content management system integration. MyHealthfinder offers an API (version 4).
• Access: Both are free. Content Syndication is available through the HHS Syndication Storefront. MyHealthfinder's API docs are on odphp.health.gov.
• Limitation: This is general health content, not patient-specific data, and you follow HHS's terms of use.

Which Fits Your App?

Start with the category that matches what your app does, then compare the APIs in it.

Many apps need more than one. For example, a telehealth app might use Stream for visits and an EHR API for patient data.

Frequently Asked Questions

Where to Find More Healthcare APIs

If none of these fit, two vendor marketplaces list more options.

• Optum now runs the Change Healthcare APIs, which cover eligibility, claims, and claim status; start at the Optum developer portal.
• NextGen Healthcare's API Marketplace lists third-party apps built on NextGen Enterprise APIs; start with the NextGen API documentation.